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Genomic Analysis Facility

The IGM’s Genomic Analysis Facility (GAF) can prepare and sequence 160 genomes or 1,500 exomes a month on four Illumina HiSeq 2500 high throughput sequencers. Library preparation and exome capture are fully automated on two Beckman Biomek FX robotic systems. The GAF also has GWAS genotyping capabilities and can process Illumina Infinium chips on Tecan and iScan robotic platforms. Follow-up genotyping is also available using the Bio-Rad QX200 digital droplet PCR system, LifeTech 7900 Fast Real-Time PCR system, or the ABI 3730 Sanger Sequencer.

Services Include:

  • Whole Genome Sequencing
  • Exome Sequencing
  • Total, Messenger, and Single-Cell RNA Sequencing
  • Custom Capture Projects
  • Library Preparation for High Throughput Sequencing
  • Illumina Infinium Genome Wide Association Studies (GWAS)
  • High Throughput Quantitative PCR
  • Automated, Digital Droplet PCR
  • TaqMan Genotyping Assays
  • Sanger Sequencing

Sequencing Core Staff

  • Colin Malone, PhD Director, Genomic Analysis and Technical Operations Assistant Professor of Medical Sciences

    Colin Malone, PhD

    • Director of Genomic Analysis and Technical Operations
      Assistant Professor, Department of Medicine

    cm3556@cumc.columbia.edu

  • Columbia Crown Illustration

    Neha Dagaonkar, MS

    • Next-Generation Sequencing Scientist and Operations Manager

    nd2544@cumc.columbia.edu

  • Caroline Mebane, Assistant Laboratory Manager

    Caroline Mebane

    • Genomic Scientist and Assistant Laboratory Manager

    cm3449@cumc.columbia.edu

  • Claude Cantave, MS

    Claude Cantave, MS

    • Genomic Scientist

  • Columbia Crown Illustration

    Dominic Nieves

    • Research Technician

  • Columbia Crown Illustration

    Jane Park

    • Research Technician