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Wendy K. Chung, MD, PhD

  • Associate Professor of Pediatrics (in Medicine)

This provider accepts new patients

Appointment Phone Number: (212) 305-5890

This provider sees pediatric patients

Wendy K. Chung, MD, PhD

Dr. Chung is a board certified clinical geneticist with a PhD in molecular genetics. She received her MD from Cornell University and her PhD from The Rockefeller University. She is director of the clinical genetics program at Columbia University, a co-director of the molecular genetics diagnostics lab, and heads a research laboratory in the division of molecular genetics investigating the genetic bases for a variety of Mendelian and complex traits.

Dr. Wendy Chung is a human geneticist whose current research activities include efforts to identify genes and their relevant allelic variants related to the development of congenital diaphragmatic hernia, congenital cardiac malformations including heterotaxy, hypoplastic left heart syndrome, cardiac septal defects, cardiomyopathies, and congenital and acquired long QT syndromes. 

In genetic studies of arrhythmias, the patient's personal history of inciting triggers, T wave morphology on ECG, and the family history are used to choose candidate genes for linkage analysis when possible and mutation identification in one of the genes/loci identified to date in long QT syndrome. 
In genetic studies of hypertrophic cardiomyopathy, the patient's history of age of onset, other associated medical problems, and family history are used to choose candidate genes for mutation identification. In studies of congenital heart disease and congenital diaphragmatic hernias, the probands are studied by comparative genomic hybridization to detect genomic alterations such as insertions or deletions on a genome wide basis. Then candidate genes are selected based upon their roles in embryonic diaphragmatic and cardiac development and screened for mutations by high throughput sequencing. Genotype-phenotype correlations are then made by comparing clinical features and outcome based on genetic etiology of a disease. Another area of research includes the identification of genes related to obesity and type 2 diabetes in mice and humans. 
Dr. Chung and associates have mapped and cloned naturally occurring spontaneous mutations in the mouse causing both monogenic forms of obesity (tubby and diabetes) as well as a suppressor of obesity called mahoganoid. We have also identified 25 quantitative trait loci (QTLs) that interact with monogenic forms of obesity to produce varying degrees of diabetes susceptibility. We have made congenic lines for most of these QTLs and have identified a QTL for diabetes call Lisch-like. 
In parallel with these rodent studies, Dr. Chung is a participant in large ongoing human genetic studies to identify the genetic susceptibility to obesity and diabetes in humans. In collaboration with investigators around the world, we have access to over 100,000 human subjects phenotyped for adiposity and have developed high throughput methods for sequencing large genomic regions for regulatory variants and have identified novel contiguous gene deletions associated with syndromic forms of obesity. 
We are also studying the molecular mechanism by which the genes FTO/FTM recently identified through large genome wide association studies cause increased adiposity. We have identified novel mutations in the Wolframin gene causing a rare autosomal recessive form of diabetes mellitus and characterized the uniparental disomy of chromosome 6 in neonates with transient neonatal diabetes. In addition, families with maturity onset diabetes of the young (MODY) and have identified a rare neonatal complication of hypoglycemia associated with MODY. 
Dr. Chung also provide the molecular genetics core services for the Obesity Research Center, Diabetes and Endocrine Research Center, Pediatric Neuromuscular Clinical Research Network studying spinal muscular atrophy, and the Pediatric Heart Network.

Board Certifications

  • Clinical Genetics and Genomics (MD)
  • Clinical Molecular Genetics and Genomics

Areas of Expertise

  • Thyroid Cancer
  • Cancer Care
  • Inborn Metabolism Disorder
  • Cleft Palate With Cleft Lip
  • Congenital Heart Disease
  • Seizures
  • Cancer Genetics
  • Arrhythmia
  • Genetic Counseling
  • Mental Retardation
  • Pediatric Seizures
  • Abdominal Hernia
  • Pancreatic Cancer
  • Pediatric Mental Retardation
  • Pulmonary Hypertension

Languages Spoken

  • Spanish

Education & Training

  • Weill Cornell Medical College
  • Internship: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center


  • Russ Berrie Medical Science Pavilion

    1150 St. Nicholas Avenue
    New York, NY 10032
    For new and current patient appointments, call:
    (212) 305-6731
    (212) 305-9058

Centers / Institutes / Programs

  • Herbert Irving Comprehensive Cancer Center

Provider Affiliations

  • NewYork-Presbyterian/Columbia

Insurance Programs

Please contact the provider's office directly to verify that your particular insurance is accepted.

  • Aetna [EPO, HMO, Medicare Managed Care, NY Signature, POS, PPO, Signature Administrators, Student Health]
  • Affinity [Essential Plan, Medicaid Managed Care, Medicare Managed Care]
  • Amida Care [Special Needs Plan]
  • Cigna [EPO, Great West, HMO, POS, PPO]
  • Emblem/GHI [HMO, Medicare Managed Care, PPO]
  • Emblem/HIP [ConnectiCare, EPO, Essential Plan, HMO, Medicaid Managed Care, Medicare Managed Care, POS, PPO, Select Care (Exchange), Vytra]
  • Empire Blue Cross Blue Shield [Blue Priority, EPO, HMO, Medicare (Mediblue), NYP Employee Plan, Pathway (Exchange), POS, PPO]
  • Empire Blue Cross Blue Shield HealthPlus [Child/Family Health Plus, Essential Plan, Medicaid Managed Care]
  • Fidelis Care [Child/Family Health Plus, Medicaid Managed Care, Medicare Managed Care]
  • Healthfirst [Child/Family Health Plus, Medicaid Managed Care, Medicare Managed Care]
  • Local 1199 [Local 1199]
  • MagnaCare [MagnaCare]
  • Multiplan [Multiplan]
  • Oxford Health Plans [Freedom, Liberty, Medicare Managed Care]
  • UnitedHealthcare [Columbia University Employee Plan, Compass (Exchange), EPO, Essential Plan, HMO, Medicaid (Community Plan), Medicare Managed Care, POS, PPO]
  • VNSNY CHOICE [Medicare Managed Care, SelectHealth]
  • WellCare [Medicaid Managed Care, Medicare Managed Care]