Search IGM

Epilepsy

We have established research programs to identify epilepsy genes and understand the molecular mechanisms behind gene mutations that cause epilepsy.  We use the latest nuclear reprogramming and genome editing techniques (CRISPR/Cas9) to generate animal, human induced pluripotent stem cell (hiPSC), and non-stem cell models of epilepsy-causing mutations to study the development and physical properties of neural networks, neurogenesis, in vivo seizure thresholds and associated behavior.  Our cell-based and animal models are also being used to discover and test new therapies designed to treat phenotypes that correlate with those seen in patients.