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We have established research programs to identify epilepsy genes and understand the molecular mechanisms behind gene mutations that cause epilepsy.  We use the latest nuclear reprogramming and genome editing techniques (CRISPR/Cas9) to generate animal, human induced pluripotent stem cell (hiPSC), and non-stem cell models of epilepsy-causing mutations to study the development and physical properties of neural networks, neurogenesis, in vivo seizure thresholds and associated behavior.  Our cell-based and animal models are also being used to discover and test new therapies designed to treat phenotypes that correlate with those seen in patients.