Search IGM

Gelinas Lab

Research Summary

Epilepsy is more than just seizures. Children and adults with epilepsy often experience problems with intellectual development, learning, memory, and attention – symptoms that can sometimes be even more disabling than seizures. In our lab, we study neural networks that mediate these cognitive functions in developing and mature brains. By understanding the physiology of these networks and how they are disrupted by epileptic activity, we work toward targeted treatments that aim not only to stop seizures, but also to address cognitive comorbidities.

Focus Areas

We use memory tasks and large-scale neural recordings in behaving rodents to understand the interplay between epileptic activity and memory. We also use closed loop technologies to perturb these neural networks with the goal of altering memory function.

We perform multi-cortical neurophysiologic recordings in wild type neonatal and juvenile rodents as well as those harboring mutations associated with epilepsy, autism, and intellectual disability to understand the unique features of these neurodevelopmental disorders.

We develop computational approaches to interictal epileptic networks using intracranial EEG data from patients with epilepsy, and leverage advanced neural interface devices to gain higher spatiotemporal resolution data from these networks.

Lab Members

  • Soledad Dominguez, Postdoctoral Research Associate
  • Naureen Ghani, Technician B

Selected Publications

  • Khodagholy D*, Gelinas JN*, Buzsaki G (2017) Learning-enhanced coupling between ripple oscillations in association cortices and hippocampus. Science 358:369-372.
  • Gelinas JN, Khodagholy D, Thesen T, Devinsky O, Buzsaki G (2016) Interictal epileptiform discharges induced hippocampal-cortical coupling in temporal lobe epilepsy. Nat Med 22: 641–648.
  • Khodagholy D*, Gelinas JN*, Zhao Z*, Yeh M, Long M, Greenlee JD, Doyle W, Devinsky O, Buzsáki G (2016) Organic electronics for high-resolution electrocorticography of the human brain. Science Advances 09 Nov 2016: DOI: 10.1126/sciadv.1601027
  • Krook-Magnusson E*, Gelinas JN*, Soltesz I, Buzsaki G (2015) Neuroelectronics and biooptics: closed-loop technologies in neurological disorders. JAMA Neurol 72:823-9.
  • Khodagholy D, Gelinas JN, Thesen T, Doyle W, Devinsky O, Malliaras G, Buzsaki G (2015) NeuroGrid: recording action potentials from the surface of the brain. Nat Neurosci 18:310-5.
  • Gelinas JN, Fitzpatrick KP, Kim HC, Bjornson BH (2014) Cerebellar language mapping and cerebral language dominance in pediatric epilepsy surgery patients. Neuroimage: Clinical 6:296-306.
  • Gelinas JN*, Liao P*, Lehman A, Stockler S, Sirrs S (2012).  Krabbe disease – a potentially treatable white matter disorder.  Neurology 79:e170-2.
  • Gelinas JN, Battison A, Smith S, Connolly MC, Steinbok P (2011).  Electrocorticography and seizure outcomes in children with lesional epilepsy. Childs Nerv Syst 27:381-90.
  • O’Dell TJ, Connor SA, Gelinas JN, Nguyen PV (2010).  Viagra for your synapses: Enhancement of long-term potentiation by activation of beta-adrenergic receptors.  Cell Signal 22: 728-36.
  • Gelinas JN, Tenorio G, Lemon N, Abel T, Nguyen PV (2008).  Beta-adrenergic receptor activation during distinct patterns of stimulation critically modulates the PKA-dependence of LTP in the mouse hippocampus.  Learn Mem 15: 281-9.
  • Gelinas JN, Banko JL, Peters MM, Klann E, Weeber EJ, Nguyen PV (2008).  Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus.  Learn Mem 15: 403-11.
  • Gelinas JN*, Banko JL*, Hou L, Sonenberg N, Weeber EJ, Klann E, Nguyen PV (2007) ERK and mTOR signalling couple beta-adrenergic receptors to translation initiation machinery to gate induction of protein synthesis-dependent LTP.  J Biol Chem 282: 27527-35.
  • Gelinas JN and Nguyen PV (2007) Neuromodulation of hippocampal synaptic plasticity, learning, and memory by noradrenaline.  Central Nervous System Agents in Medicinal Chemistry 7:1-17.
  • Gelinas JN and Nguyen PV (2005) Beta-adrenergic receptor activation facilitates induction of a protein synthesis-dependent late phase of long-term potentiation.  J Neurosci 25:3294-3303.

Education

  • PhD, Neuroscience, University of Alberta
  • MD, University of Alberta
  • FRCPC, Pediatric Neurology, University of British Columbia

Positions

  • Assistant Professor of Neurology (in the Institute for Genomic Medicine and the Gertrude H. Sergievsky Center), Division of Child Neurology